Immune-focused library is generated using B cells of various animal species which have immunized with the specific antigen. Immune-focused library construction and screening service is designed to isolate specific and high affinity antibodies against the target of interest compared with the antibodies discovered from the naïve antibody library.
Y-Biologics offers the construction of the immune-focused library in the form of a phage display library by using cDNA extracted from mouse spleens and suggests antibody screening service with optimized panning methods against the target to discover antibodies with high affinity. We also propose antibody optimization(See more) including antibody maturation and humanization if clients would like to develop the antibodies generated from immune-focused library as a therapeutic purpose to reduce the immunogenicity and enhance the binding affinity.
Deliverables: Final report, Antibody variable region sequences
higher binding affinity
construction and screening with our related service, Antibody Humanization. Click here to learn details